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Karolinska Institutet researchers report a single-injection AAV gene therapy delivering the OTOF gene into the inner ear improved hearing in all 10 participants with congenital OTOF-related deafness. Injections via the round window at five Chinese hospitals; most regained hearing within a month, and by six months all showed improvement. Average hearing sensitivity rose from about 106 dB to 52 dB. Younger children (especially ages 5–8) showed the strongest gains; the treatment was safe with no serious adverse events, minor neutrophil decreases. Plans to expand to other deafness genes (GJB2, TMC1).
Expert judgment is learnable but not teachable; it arises from calibration across high-dimensional inputs, not from language transfer. Language transmits only low-dimensional rules; real expertise comes from perceptual calibration developed through thousands of real-world exposures. A road-crossing example shows many interacting variables; rule-based transmission fails because non-additive, context-dependent interactions matter. Metrics privilege legible, book-smart knowledge over experiential judgment, weakening performance in non-routine cases. There is a hierarchy of transmissibility: facts and explicit rules; formal models; heuristics; perceptual calibration (hardest). Organizations codify, degrading non-transmissible expertise; true expertise requires prolonged calibration, not scalable training.
Plague Ships traces how infectious disease spread via ships and how authorities battled it long before COVID. It covers the yellow flag (healthy ship) practice since 1887, medieval yellow associations, Dubrovnik’s 30‑day waits, Venice’s health checks and 40‑day quarantines with fumigation, and the Santa Maria di Nazareth isolation hospital (1423). It recounts the Black Death’s European toll and probable maritime origin, then the 1918 Spanish Flu (Kansas Army camp origin) and its deadly waves and failed distancing. It ends by contrasting modern naming with historical lessons.
Adam Zieliński reflects on Butterick’s Practical Typography, arguing that good typography should reinforce meaning, be text-specific, and acknowledge that no single solution fits all. He likens typography to theater: like an actor interpreting a script, typographic choices shape meaning. He highlights practical takeaways: use SVG for consistent rendering, learn mac curly quote shortcuts, understand hyphenation with ­, distinguish letter-spacing from kerning, critique link capitalization, avoid overreliance on tables/floats, and prefer careful borders and grid use. Encourages readers to consult Practical Typography.
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HYBRO Hub is a lightweight daemon that unifies local AI agents (e.g., Ollama) with cloud agents in hybro.ai, all in one portal. It keeps data private on your machine—outbound-only connections, no inbound ports, and a privacy router that processes locally when possible. Install with pip install hybro-hub, generate an API key, and run hybro-hub start. Hub auto-discovers local agents, syncs them to the cloud, and shows them beside cloud agents in the UI. Supports A2A protocol, auto/manual discovery, and adapters (Ollama, OpenClaw, n8n). Config: ~/.hybro/config.yaml.
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Astronomers have found a third ultra-diffuse galaxy, NGC 1052-DF9 (DF9), seemingly devoid of dark matter, joining DF2 and DF4 and strengthening the Bullet Dwarf collision theory. In this scenario, two gas-rich dwarfs collide at high speed; their dark matter halos pass through, while gas collides, triggering star formation and leaving dark-matter-free remnants. The pattern across DF2, DF4, and DF9 challenges MOND and supports dark matter as a real substance. Hubble confirmed DF2’s distance; researchers hope to study more galaxies along the trail.
New York Fed data show legal sports betting is linked to weaker consumer finances: credit delinquencies rose about 0.3% in states where betting is legal, and more than 10% among the 3% who started betting after legalization. March Madness bets are projected at $3.3 billion; betting spending more than doubled since 2019. A UCLA study found legalization associated with lower average credit scores; in online-betting states, bankruptcy rose about 10% and debt collections 8% two years after legalization. Experts warn of gambling addiction; industry cites responsible gaming and declining ad spend.
Bloomberg's bot-detection page warns of unusual activity and asks users to verify they're not a robot, ensure JavaScript and cookies are enabled, and review the Terms of Service and Cookie Policy. It directs users to contact support with a block reference ID if needed and includes a Bloomberg subscription prompt.
WSJ 404 error page: the requested page can’t be found. Provides support email and a list of popular articles (Iranian strike on the U.S. Embassy; Inside story of Pam Bondi’s ouster; Trump joked about Macron’s wife) plus latest market podcasts.
ClickHouse vs Pinot for Real-Time Analytics: ClickHouse is a single-binary, columnar MergeTree DB optimized for batch and streaming ingestion with strong compression; Pinot is a multi-component system with real-time and offline segments, Kafka-centric and ZooKeeper/Helix-backed. Ingestion latency: ClickHouse ~1–5s batch; Pinot often sub-second. Query language: ClickHouse SQL extensions; Pinot uses PQL with SQL-like features. Storage/performance: ClickHouse is suited for complex analytics over large histories; Pinot for low-latency, high-concurrency user dashboards. Ops: Pinot has more moving parts. Choose ClickHouse for ad-hoc and batch analytics; Pinot for real-time dashboards with strict SLAs.
Apple approved a Tiny Corp driver that enables Nvidia eGPUs to run on Arm Macs. It's not plug-and-play—users must compile it with Docker—and it's aimed at running large-language-model workloads. The driver can be signed by Apple, so SIP doesn’t need to be disabled, and it supports both AMD and Nvidia GPUs.
Tristan da Cunha, the world’s most remote inhabited island, has 221 residents in Edinburgh of the Seven Seas. With no airport and few ships, life is intensely communal and self-reliant, tasks shared across families. The economy centers on lobster and crawfish fishing and potato farming; livestock and field work fill days from dawn to dusk. Daily life weaves school, fisheries, processing, and celebrations like christenings. A history of gradual change—WWII cash wages, a 1949 lobster fishery, and a 1961 eruption evacuation—gives way to modern upgrades: electricity, satellite internet, and growing tourism and conservation work. Everyone does everything.
Product page lists several AI models (e.g., llama-4-scout-109b, qwen-3.5-122b, glm-5-754b, kimi-k2.5-1t, deepseek-v3.2-685b, deepseek-r1-0528-685b) with two pricing/commitment options: $10 for 1 month at 15 tok/s (0% availability) and $40 for 3 months at 35 tok/s (100% availability). Filters let you sort by Availability, Price, Throughput; shows 0 of 0 results; no cohorts match.
LLM-generated passwords are insecure by design. Since LLMs predict tokens rather than sampling uniformly from a character set, they produce biased, repetitive passwords with low entropy. Tests across Claude, GPT-5.2, Gemini, and Gemini 3 Flash show frequent patterns (e.g., common starts like G7$, limited symbol usage) and high repetition, yielding effective entropy around 20–27 bits instead of 100+ bits for truly random passwords. Coding agents also favor LLM passwords depending on prompts. Recommendation: do not rely on LLM outputs for passwords; use cryptographically secure PRNGs (openssl rand, /dev/random) and password managers, and audit/rotate any LLM-generated credentials.
Germany's Military Service Modernization Act, effective Jan 2026, requires men aged 18–46 to obtain Bundeswehr approval before leaving the country for more than three months. The permit, issued by the Bundeswehr Career Center, can apply even for study or work abroad and is for wartime planning. The law aims to raise active-duty personnel from about 180,000 to 260,000 by 2035 while keeping service voluntary. From 2027, 18-year-olds will undergo a fitness test to gauge draft eligibility; protests accompanied the debate, and penalties for violations remain unclear.
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